Gene
kbtbd7
- ID
- ZDB-GENE-070912-204
- Name
- kelch repeat and BTB (POZ) domain containing 7
- Symbol
- kbtbd7 Nomenclature History
- Previous Names
-
- si:ch211-221b16.9
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of Rac protein signal transduction. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in telencephalon. Orthologous to several human genes including KBTBD7 (kelch repeat and BTB domain containing 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-kbtbd7 | N/A | Feng et al., 2021 |
| MO2-kbtbd7 | N/A | Feng et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR011705 | BTB/Kelch-associated |
| Domain | IPR047931 | KBTBD6/KBTBD7, BACK domain |
| Domain | IPR047933 | KBTBD6/KBTBD7, BTB/POZ domain |
| Family | IPR017096 | BTB-kelch protein |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR015915 | Kelch-type beta propeller |
| Repeat | IPR006652 | Kelch repeat type 1 |
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/Kelch-associated | BTB-kelch protein | BTB/POZ domain | KBTBD6/KBTBD7, BACK domain | KBTBD6/KBTBD7, BTB/POZ domain | Kelch repeat type 1 | Kelch-type beta propeller | SKP1/BTB/POZ domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PRY0 | InterPro | 621 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kbtbd7-201
(1)
|
Ensembl | 1,927 nt | ||
| mRNA |
kbtbd7-202
(1)
|
Ensembl | 1,866 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-221B16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001334195 (1) | |||
| Genomic | GenBank:BX510646 (1) | 200321 nt | ||
| Polypeptide | UniProtKB:A0A8M1PRY0 (1) | 621 aa |
- Feng, D., Wang, J., Yang, W., Li, J., Lin, X., Zha, F., Wang, X., Ma, L., Choi, N.T., Mii, Y., Takada, S., Huen, M.S.Y., Guo, Y., Zhang, L., Gao, B. (2021) Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation. Science advances. 7(20):
- Lin, J., Liang, J., Wen, J., Luo, M., Li, J., Sun, X., Xu, X., Li, J., Wang, D., Wang, J., Chen, H., Lai, R., Liang, F., Li, C., Ye, F., Zhang, J., Zeng, J., Yang, S., Sheng, W. (2020) Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 41(6):1251-1263
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Feiner, N., Murakami, Y., Breithut, L., Mazan, S., Meyer, A., and Kuraku, S. (2013) Saltatory evolution of the ectodermal neural cortex (ENC) gene family at the vertebrate origin. Genome biology and evolution. 5(8):1485-502
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